混合现实技术在护理领域的应用现状

混合现实技术是当前数字医学关注的热点。围绕混合现实技术在护理领域中的应用,从混合现实技术的概述,混合现实技术在护理教学、护理培训、医护沟通及护患沟通等方面的应用现状及发展前景进行综述,以期为混合现实的护理实践领域研究提供新思路。     

医联体基层医院联络护士压力性损伤护理的同质化培训

目的 提高医联体基层医院联络护士压力性损伤护理能力。 方法 选取医联体内3所基层医院28名压力性损伤联络护士为培训对象,由医联体主体医院的造口伤口失禁专科护理团队构建压力性损伤护理同质化培训方案,采取线上对分课堂与线下工作坊实践相结合的方式培训19学时,并进行6个月临床在岗压力性损伤护理实践。 结果 培训后,联络护士压力性损伤管理自我效能感得分、压力性损伤护理知识得分、压力性损伤同质化护理实践能力得分显著高于实践前（均P＜0.05）,学员对培训的总体满意度达92.8%。 结论 对医联体基层医院联络护士开展压力性损伤护理同质化培训能有效提高其压力性损伤知识和护理实践能力。     

纳米技术介导的光动力疗法治疗肝细胞癌的研究进展

肝脏恶性肿瘤包括原发性和转移性肿瘤,肝细胞癌又是肝脏恶性肿瘤中最常见的类型。然而,目前临床上常用的治疗手段在提高不宜手术的晚期肝细胞癌患者生存率方面取得的进展有限。因此,肝细胞癌的临床治疗除了手术、放化疗、经动脉化疗栓塞治疗、射频消融治疗、介入治疗、靶向治疗以及免疫治疗外,急需一种新的治疗方式。光动力疗法(PDT)是治疗晚期癌症的一种新策略,其为患者提供了一种微创、低毒副作用的潜在治疗方法,且在整个治疗过程是无痛、可重复的。因此,光动力疗法被认为是治疗晚期肝细胞癌的有效姑息疗法。纳米技术介导的光动力治疗可以有效的提高光敏剂在体内的靶向性,从而提高治疗效果。本文就纳米技术介导的光动力治疗在肝细胞癌中的应用作一综述。     

Dual-centre randomized-controlled trial comparing transurethral endoscopic enucleation of the prostate using diode laser vs. bipolar plasmakinetic for the treatment of LUTS secondary of benign prostate obstruction: 1-year follow-up results

Purpose

Bipolar endoscopic enucleation of the prostate (BEEP) was recommended by the 2016 EAU guidelines as the first choice of surgical treatment in men with a substantially enlarged prostate and moderate-to-severe lower urinary tract symptoms. The main aim of this study was to compare a modified diode laser enucleation of the prostate (DiLEP) to BEEP.

Methods

A total of 114 patients with prostate (20–160 mL) were randomized 1:1 into either DiLEP or BEEP in a dual-centre, non-inferiority-design randomized-controlled trial. The primary outcomes included Q_max and IPSS at 12 months. Non-inferiority was evaluated by comparing the two-sided 95% CI for the mean differences of Q_max and IPSS. Secondary endpoints included other perioperative parameters, postoperative micturition variables, and complication rate.

Results

A total of 111 patients (97%) had completed the intent-to-treat analysis, The results showed that DiLEP was comparable to BEEP regarding Q_max (28.0 ± 7.0 vs. 28.1 ± 7.2 mL/s) and IPSS (3.0 ± 2.2 vs. 2.9 ± 2.6) at 12 months, the non-inferiority was met for both Q_max and IPSS. There were also no significant difference between two groups regarding tissue removal rate (71.8 vs. 73.8%), hemoglobin decrease (0.33 ± 0.66 vs. 0.36 ± 0.75 g/dL), sodium decrease (1.0 ± 2.7 vs. 0.3 ± 2.9 mmol/L), and Clavien III complications (5.3 vs. 1.8%) at 12 months.

Conclusions

This DiLEP is an anatomical endoscopic enucleation technique for the treatment of benign prostatic hyperplasia, it is non-inferior to BEEP regarding Q_max and IPSS at 12 months postoperatively.

     

The effect of metabolic surgery on nonobese patients (BMI<30 kg/m2) with type 2 diabetes: a systematic review

Background

The influence of metabolic surgery on the glucose and lipid profiles of nonobese body mass index<30 kg/m² patients with type 2 diabetes, particularly the effect ≥1 year, remains unknown.

姜黄素对脂多糖诱导肺细胞损伤的作用及其机制研究

目的 探究姜黄素通过介导长链非编码RNA THRIL（lncRNA THRIL）表达对脂多糖（LPS）诱导的人正常肺上皮细胞（BEAS-2B）损伤的影响。方法 LPS诱导BEAS-2B细胞复制体外急性肺损伤细胞模型,并加入姜黄素处理。采用Lipofectamine^?2000转染试剂将lncRNA THRIL过表达/敲降载体或空载体转染到BEAS-2B细胞中。通过实时荧光定量聚合酶链反应和酶联免疫吸附试验检测lncRNA THRIL及炎症细胞因子［白细胞介素1β（IL-1β）、白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）］水平;CCK-8法和流式细胞术分别检测LPS、姜黄素及THRIL对细胞活性和细胞凋亡的影响。结果 姜黄素组与对照组lncRNA THRIL相对表达量比较,差异无统计学意义（P >0.05）,LPS组较对照组升高（P <0.05）,LPS+姜黄素2.5 μmol/L组、LPS+姜黄素5 μmol/L组、LPS+姜黄素7.5 μmol/L组较LPS组降低（P <0.05）。姜黄素组与对照组细胞凋亡率比较,差异无统计学意义（P >0.05）,LPS组较对照组升高（P <0.05）,LPS+姜黄素2.5 μmol/L组、LPS+姜黄素5 μmol/L组、LPS+姜黄素7.5 μmol/L组较LPS组降低（P <0.05）。姜黄素组与对照组IL-1β、IL-6和TNF-α相对表达量及浓度比较,差异无统计学意义（P >0.05）,LPS组较对照组升高（P <0.05）,LPS+姜黄素2.5 μmol/L组、LPS+姜黄素5 μmol/L组、LPS+姜黄素7.5 μmol/L组较LPS组降低（P <0.05）。姜黄素组与对照组细胞活性比较,差异无统计学意义（P >0.05）,LPS组较对照组降低（P <0.05）,LPS+姜黄素2.5 μmol/L组、LPS+姜黄素5 μmol/L组、LPS+姜黄素7.5 μmol/L组较LPS组升高（P <0.05）。敲降THRIL组lncRNA THRIL的相对表达量较敲降阴性对照组降低（P <0.05）。LPS+敲降阴性对照组与LPS组细胞凋亡率比较,差异无统计学意义（P >0.05）,LPS组较对照组升高（P <0.05）,LPS+敲降THRIL组较LPS+敲降阴性对照组降低（P <0.05）。LPS+敲降阴性对照组与LPS组IL-1β、IL-6和TNF-α的相对表达量及浓度比较,差异无统计学意义（P >0.05）,LPS组较对照组升高（P <0.05）,LPS+敲降THRIL组较LPS+敲降阴性对照组降低（P <0.05）。LPS+敲降阴性对照组与LPS组细胞活性比较,差异无统计学意义（P >0.05）,LPS组较对照组降低（P <0.05）,LPS+敲降THRIL组较LPS+敲降阴性对照组升高（P <0.05）。过表达THRIL组lncRNA THRIL相对表达量较过表达阴性对照组升高（P <0.05）。LPS+姜黄素+过表达阴性对照组与LPS+姜黄素组细胞活性比较,差异无统计学意义（P >0.05）,LPS组较对照组降低（P <0.05）,LPS+姜黄素组较LPS组升高（P <0.05）,LPS+姜黄素+过表达THRIL组较LPS+姜黄素+过表达阴性对照组细胞活性降低（P <0.05）。LPS+姜黄素+过表达阴性对照组与LPS+姜黄素组细胞凋亡率比较,差异无统计学意义（P >0.05）,LPS组较对照组升高（P <0.05）,LPS+姜黄素组较LPS组降低（P <0.05）,LPS+姜黄素+过表达THRIL组较LPS+姜黄素+过表达阴性对照组升高（P <0.05）。LPS+姜黄素+过表达阴性对照组与LPS+姜黄素组IL-1β、IL-6和TNF-α的相对表达量及浓度比较,差异无统计学意义（P >0.05）,LPS组较对照组升高（P <0.05）,LPS+姜黄素组较LPS组降低（P <0.05）,LPS+姜黄素+过表达THRIL组较LPS+姜黄素+过表达阴性对照组升高（P <0.05）。结论 姜黄素通过抑制THRIL表达,改善LPS诱导的BEAS-2A细胞凋亡和炎症反应。